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Advances in the study of directed evolution for cellulases

Hailong LIN, Weiguang LI, Changhong GUO, Sihang QU, Nanqi REN

Frontiers of Environmental Science & Engineering 2011, Volume 5, Issue 4,   Pages 519-525 doi: 10.1007/s11783-011-0326-2

Abstract: Application of directed evolution technology may be one of the most effective ways for improving thehydrolysis mechanism by cellulase, advances in cellulases (endoglucanase and -glucosidase) improvement by directedevolution for several characteristics (for instance, thermal stability, pH adaptability and enzyme activity), limitations of directed evolution for cellulases, and the outlook for directed evolution for cellulase

Keywords： biohydrogen     bioethanol     cellulase     cellulose     directed evolution    

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Development of a dual temperature control system for isoprene biosynthesis in

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 7,   Pages 1079-1089 doi: 10.1007/s11705-021-2088-0

Abstract: A cold-sensitive mutant, Gal4ep19, was created by directed evolution of Gal4p based on an internallyThis study reports the creation of the first cold-sensitive variants of Gal4p by directed evolution and

Keywords： transcriptional activator     directed evolution     dynamic control     heat-shock     isoprene    

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Unnormalized and normalized forms of gefura measures in directed and undirected networks

Raf GUNS,Ronald ROUSSEAU

Frontiers of Information Technology & Electronic Engineering 2015, Volume 16, Issue 4,   Pages 311-320 doi: 10.1631/FITEE.1400425

Abstract: latter normalizes at the level of nodes. (2) Treating undirected networks as equivalent to symmetric directednetworks, we expand the definition of gefura measures to the directed case. (3) It is shown how Brandes

Keywords： Networks subdivided in groups     Partitions     Gefura measures     Q-measures     Brokerage role     Directed and    

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Controllability analysis of second-ordermulti-agent systemswith directed andweighted interconnection

Di GUO,Rong-hao ZHENG,Zhi-yun LIN,Gang-feng YAN

Frontiers of Information Technology & Electronic Engineering 2015, Volume 16, Issue 10,   Pages 838-847 doi: 10.1631/FITEE.1500069

Abstract: Each agent is assumed to be governed by a second-order consensus control law corresponding to a directedThe first is concerned with directed trees, which represent the class of topology with minimum informationThe second is concerned with a more general graph that can be reduced to a directed tree by contracting

Keywords： Multi-agent systems     Controllability     Directed tree    

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Ionic strength directed self-assembled polyelectrolyte single-bilayer membrane for low-pressure nanofiltration

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 5,   Pages 699-708 doi: 10.1007/s11705-021-2093-3

Abstract: In this work, an ionic strength directed self-assembly procedure is described for the preparation of

Keywords： layer-by-layer self-assembly     single bilayer     nanofiltration membrane     desalination    

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Liver-directed treatment is associated with improved survival and increased response to immune checkpoint

Frontiers of Medicine   Pages 878-888 doi: 10.1007/s11684-023-0993-y

Abstract: Due to low response rates to systemic therapies, liver-directed therapies (LDT) are commonly used for

Keywords： uveal melanoma     liver-directed therapy     immune checkpoint blockade     SIRT     anti-PD-1     anti-CTLA-4    

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Clinical outcomes of ATP-tumor chemosensitivity assay directed chemotherapy in hepatocellular carcinoma

RAO Rongsheng, CHEN Wenxue, ZHOU Xinwen, ZHOU Zheng, LI Xiaojun, ZENG Zhiping

Frontiers of Medicine 2007, Volume 1, Issue 2,   Pages 157-160 doi: 10.1007/s11684-007-0029-z

Abstract: This study aims to investigate the clinical response of ATP tumor chemosensitivity assay (ATP-TCA) directedIn short, ATP-TCA directed chemotherapy shows better results for terminal stages of PLC in that you can
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Site-directed mutagenesis of long QT syndrome KCNQ1 gene

LI Wei, WANG Bin, XU Qiumei, KE Qinmei, YANG Junguo, DU Rong, TIAN Li, WANG Qing

Frontiers of Medicine 2008, Volume 2, Issue 1,   Pages 100-104 doi: 10.1007/s11684-008-0018-x

Abstract: To construct a polymerase chain reaction (PCR) site-directed mutagenesis of the long QT syndrome KCNQ1

Keywords： restriction     digestion     syndrome     sequence     site-directed mutagenesis    

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oocyst directed assembly of gold nanoparticles and graphene oxide

Sona Jain, Zhicheng Huang, Brent R. Dixon, Syed Sattar, Juewen Liu

Frontiers of Chemical Science and Engineering 2019, Volume 13, Issue 3,   Pages 608-615 doi: 10.1007/s11705-019-1813-4

Abstract: Understanding the interactions between inorganic nanomaterials and biological species is an important topic for surface and environmental chemistry. In this work, we systematically studied the oocysts of as a model protozoan parasite and its interaction with gold nanoparticles (AuNPs) and graphene oxide (GO). The as-prepared citrate-capped AuNPs adsorb strongly on the oocysts leading to a vivid color change. The adsorption of the AuNPs was confirmed by transmission electron microscopy. Heat treatment fully inhibited the color change, indicating a large change of surface chemistry of the oocysts that can be probed by the AuNPs. Adding proteases such as trypsin and proteinase K partially inhibited the color change. DNA-capped AuNPs, on the other hand, could not be adsorbed by the oocysts. GO was found to wrap around the oocysts forming a conformal shell reflecting the shape of the oocysts. Both citrate-capped AuNPs and GO compromised the membrane integrity of the oocysts as indicated by the propidium iodide staining experiment, and they may be potentially used for inactivating the oocysts. This is the first example of using nanomaterials to probe the surface of the oocysts, and it suggests the possibility of using such organisms to template the assembly of nanomaterials.

Keywords： nanomaterials     toxicology     water     biosensors    

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Optimized human factor IX expression cassettes for hepatic-directed gene therapy of hemophilia B

Ru Zhang,Qiang Wang,Lin Zhang,Saijuan Chen

Frontiers of Medicine 2015, Volume 9, Issue 1,   Pages 90-99 doi: 10.1007/s11684-015-0390-2

Abstract: therapy provides a potential cure for hemophilia B, and significant progress has been achieved in liver-directed

Keywords： factor IX     hemophilia B     liver-specific regulatory elements     hydrodynamic gene transfer    

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Tuned reactive power dispatch through modified differential evolution technique

S. BISWAS (RAHA), N. CHAKRABORTY

Frontiers in Energy 2012, Volume 6, Issue 2,   Pages 138-147 doi: 10.1007/s11708-012-0188-8

Abstract: This paper explores the capability of modified differential evolution (MDE) technique for solving theThe proposed method is based on the basic differential evolution (DE) technique with a few modifications

Keywords： reactive power dispatch (RPD)     modified differential evolution (MDE)     differential evolution algorithm    

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Strategic Thinking on a Revolution/an Evolution in Production and Consumption of Energy in China

Ke-chang Xie,Ke Liu

Frontiers of Engineering Management 2014, Volume 1, Issue 1,   Pages 30-36 doi: 10.15302/J-FEM-2014006

Abstract: This article summarizes the thinking behind the call for a revolution/an evolution in China's energyAction plans are presented to support the call for a revolution/an evolution in China's energy production

Keywords： revolution     evolution     energy     production     consumption    

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Minimal residual disease-directed immunotherapy for high-risk myelodysplastic syndrome after allogeneic

Xiaodong Mo, Xiaohui Zhang, Lanping Xu, Yu Wang, Chenhua Yan, Huan Chen, Yuhong Chen, Wei Han, Fengrong Wang, Jingzhi Wang, Kaiyan Liu, Xiaojun Huang

Frontiers of Medicine 2019, Volume 13, Issue 3,   Pages 354-364 doi: 10.1007/s11684-018-0665-5

Abstract: The efficacy of minimal residual disease (MRD)-directed immunotherapy, including interferon- (IFN- )Thus, the MRD-directed immunotherapy was effective for patients with high-risk MDS who were MRD-positive

Keywords： donor leukocyte infusion     hematopoietic stem cell transplantation     interferon-   

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Polypyrrole@NiCo hybrid nanotube arrays as high performance electrocatalyst for hydrogen evolution reaction

Shenghua Ye, Gaoren Li

Frontiers of Chemical Science and Engineering 2018, Volume 12, Issue 3,   Pages 473-480 doi: 10.1007/s11705-018-1724-9

Abstract: nanotube arrays have been successfully fabricated as a high performance electrocatalyst for hydrogen evolution

Keywords： NiCo alloy     polypyrrole     hybrid nanotube     electrocatalyst     hydrogen evolution reaction    

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Synergistic effect of V and Fe in Ni/Fe/V ternary layered double hydroxides for efficient and durable oxygen evolution

Frontiers of Chemical Science and Engineering 2023, Volume 17, Issue 1,   Pages 102-115 doi: 10.1007/s11705-022-2179-6

Abstract: High-performance and stable electrocatalysts are vital for the oxygen evolution reaction (OER).

Keywords： oxygen evolution reaction     electrocatalysts     ternary layered double hydroxides     long-term stability    

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Title Author Date Type Operation

Advances in the study of directed evolution for cellulases

Hailong LIN, Weiguang LI, Changhong GUO, Sihang QU, Nanqi REN

Journal Article

Development of a dual temperature control system for isoprene biosynthesis in

Journal Article

Unnormalized and normalized forms of gefura measures in directed and undirected networks

Raf GUNS,Ronald ROUSSEAU

Journal Article

Controllability analysis of second-ordermulti-agent systemswith directed andweighted interconnection

Di GUO,Rong-hao ZHENG,Zhi-yun LIN,Gang-feng YAN

Journal Article

Ionic strength directed self-assembled polyelectrolyte single-bilayer membrane for low-pressure nanofiltration

Journal Article

Liver-directed treatment is associated with improved survival and increased response to immune checkpoint

Journal Article

Clinical outcomes of ATP-tumor chemosensitivity assay directed chemotherapy in hepatocellular carcinoma

RAO Rongsheng, CHEN Wenxue, ZHOU Xinwen, ZHOU Zheng, LI Xiaojun, ZENG Zhiping

Journal Article

Site-directed mutagenesis of long QT syndrome KCNQ1 gene

LI Wei, WANG Bin, XU Qiumei, KE Qinmei, YANG Junguo, DU Rong, TIAN Li, WANG Qing

Journal Article

oocyst directed assembly of gold nanoparticles and graphene oxide

Sona Jain, Zhicheng Huang, Brent R. Dixon, Syed Sattar, Juewen Liu

Journal Article

Optimized human factor IX expression cassettes for hepatic-directed gene therapy of hemophilia B

Ru Zhang,Qiang Wang,Lin Zhang,Saijuan Chen

Journal Article

Tuned reactive power dispatch through modified differential evolution technique

S. BISWAS (RAHA), N. CHAKRABORTY

Journal Article

Strategic Thinking on a Revolution/an Evolution in Production and Consumption of Energy in China

Ke-chang Xie,Ke Liu

Journal Article

Minimal residual disease-directed immunotherapy for high-risk myelodysplastic syndrome after allogeneic

Xiaodong Mo, Xiaohui Zhang, Lanping Xu, Yu Wang, Chenhua Yan, Huan Chen, Yuhong Chen, Wei Han, Fengrong Wang, Jingzhi Wang, Kaiyan Liu, Xiaojun Huang

Journal Article

Polypyrrole@NiCo hybrid nanotube arrays as high performance electrocatalyst for hydrogen evolution reaction

Shenghua Ye, Gaoren Li

Journal Article

Synergistic effect of V and Fe in Ni/Fe/V ternary layered double hydroxides for efficient and durable oxygen evolution

Journal Article